In order to replace the spark plugs, you don't need to remove the supercharger, but you may have to move some things for access. IIRC, in order to get to it from the top, you need to remove the lower boost pipe.
Remove ignition wires. I tend to remove one wire and plug, and replace as I go, instead of all at once.
Remove spark plugs.
From repair manual: NOTE: Three different styles of Platinum enhanced spark plugs are produced for this engine. Each plug has a different part number, and use. AWSF-34P (depending upon application) spark plugs have a platinum enhanced center electrode and are used in cylinders 4, 5, and 6. AWSF-34PG (depending upon application) spark plugs have a platinum enhanced ground (side) electrode, and are used in cylinders 1, 2, and 3. If any spark plug is removed and reinstalled, it MUST be installed in the same cylinder from which it was removed. If any spark plug is replaced, use only spark plugs with part number AWSF-34PP (as listed on the VECI label). This replacement spark plug has double platinum enhancement on both the center and ground electrode and may be used in all six cylinders.
The spark plug change (with wires) is listed as a 2 hour job, but I'd say it's more like 3-4 hours for teh home mechanic.